Motilium replacements: what to try when domperidone isn’t right for you

Can’t use Motilium (domperidone) or worried about its side effects? You’ve got several real options — both medicines and simple non-drug fixes. This page breaks down practical replacements, the main risks to watch for, and quick tips so you can talk to your doctor without getting lost in jargon.

When to choose a drug replacement

Pick a drug based on why you need Motilium: nausea, vomiting, or slow stomach emptying (gastroparesis). Here are common alternatives and what to expect:

Metoclopramide — a true prokinetic that helps stomach emptying and relieves nausea. Works well short-term, but long-term use can cause movement side effects (tardive dyskinesia). Doctors usually limit dose and duration.

Ondansetron — great for acute vomiting, especially after surgery or chemo. It’s less useful as a long-term prokinetic, and it can affect heart rhythm (QT prolongation) in some people.

Promethazine (Phenergan) — an older anti-nausea drug that works for motion sickness and general nausea. It’s sedating, so avoid driving or heavy machinery after using it. See our Phenergan guide for details.

Erythromycin (low dose) — an antibiotic that can act as a motility stimulant. Often used short-term for gastroparesis. Because it’s an antibiotic, doctors avoid long courses to prevent resistance and interactions.

Itopride, mosapride, levosulpiride — available in some countries as prokinetics with fewer central nervous system effects. Ask your prescriber if these are legal and available where you live.

Non-drug fixes and safety tips

Not every problem needs a pill. Try small, frequent meals, lower-fat foods, and sitting upright after eating. Ginger, peppermint, or dietary changes often reduce mild nausea. If you’re ordering meds online, check our online pharmacy reviews and customs rules to avoid unsafe sources.

Important safety notes: domperidone has been linked to heart rhythm issues in higher doses or when combined with certain medicines. Always tell your doctor about heart disease, low potassium, or other drugs you take (some interact badly with anti-nausea meds). If you’re older, pregnant, or breastfeeding, talk with a clinician before switching.

Want help picking one? A good approach: explain exactly why Motilium was prescribed (nausea vs slow motility), list other health issues, and ask about short-term vs long-term risks. Your provider can suggest tests (like an ECG) if heart risk is a concern and choose the safest alternative for you.

If you’re exploring options beyond prescription drugs — like supplements or lifestyle changes — read our related guides and pharmacy reviews to stay safe and get the right product. Every change should come with a clear plan and a follow-up to check that it’s working without harm.